GenomicsbioRxivPreprint
Exposure to PM2.5 during pregnancy or lactation increases methylation while reducing the expression of Pdx1 and NEUROG3 in mouse pancreatic islets
Raquel Patrícia Ataíde Lima, Vitor Ferreira Boico, Guilherme Francisco Peruca…·Patrícia O. Prada
This study shows that maternal exposure to PM2.5 during pregnancy or lactation increases DNA methylation and reduces expression of Pdx1 and NEUROG3 in mouse pancreatic islets, leading to multigenerational glucose homeostasis issues.
DOI 10.1101/852509