Astrocyte-Derived Exosomes Regulate Sperm miR-34c Levels to Mediate the Transgenerational Effects of Paternal Chronic Social Instability Stress
Alexandre Champroux, Mitra‐Sadat Sadat‐Shirazi, Xuan Chen, Jonathan Hacker, Yongjie Yang, Larry A. Feig
This study shows that paternal chronic social instability stress reduces sperm miR-34c levels via astrocyte-derived exosomes, which are transmitted to offspring and contribute to transgenerational stress-related traits.
Epigenetics · Jan 27, 2025Peer-reviewedGenetics