In vivo Imaging β-cell Function Reveals Two Waves of β-cell Maturation
Jia Zhao, Weijian Zong, Yi Wu, Jiayu Shen, Dongzhou Gou, Yiwen Zhao, Runlong Wu, Fuzeng Niu, Xu Wang, Xuan Zheng, Aimin Wang, Yunfeng Zhang, Jing‐Wei Xiong, Liangyi Chen, Yanmei Liu
This study uses in vivo imaging in zebrafish to show that β-cell maturation occurs in two waves, initiated by low glucose and boosted by increased glucose delivery, with calcineurin/NFAT activation playing a key role.
bioRxiv · Jul 5, 2017 · PreprintDevelopmental Biology