Runlong Wu

A versatile miniature two-photon microscope enabling multicolor deep-brain imaging

The paper introduces a miniature two-photon microscope for deep-brain imaging in freely behaving mice, achieving high-resolution imaging of neuronal activity and amyloid plaques.

An optimized acetylcholine sensor for monitoring in vivo cholinergic activity

The paper develops an optimized GRABACh sensor to measure in vivo cholinergic activity in Drosophila and mice, revealing compartmental ACh signals and single-trial dynamics.

In vivo Imaging β-cell Function Reveals Two Waves of β-cell Maturation

This study uses in vivo imaging in zebrafish to show that β-cell maturation occurs in two waves, initiated by low glucose and boosted by increased glucose delivery, with calcineurin/NFAT activation playing a key role.