Author

Arnoud Boot

Duke-NUS Medical SchoolORCID 0000-0002-7717-7416Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Research Focus:variant calling· 1 Assay:whole-exome sequencing· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Steve RozeniD· 3 shared Alvin Wei Tian NgiD· 1 shared Daniel S.W. TaniD· 1 shared Fui Teen Chong· 1 shared Mo LiuiD· 1 shared Nanhai JiangiD· 1 shared Narayanan Gopalakrishna IyeriD· 1 shared Szu-Chi Ho· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersGenomics

Steve RozenORCID

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3 papers

Recent·Most cited

BioinformaticsNAR Genomics and BioinformaticsPeer-reviewedJan 10, 2023

mSigHdp: hierarchical Dirichlet process mixture modeling for mutational signature discovery

Mo Liu, Yang Wu, Nanhai Jiang…·Steve Rozen

mSigHdp improves mutational signature discovery using hierarchical Dirichlet process mixture models, outperforming NMF-based methods on synthetic data.

21 citations

whole-genome sequencingstatistical model

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GenomicsGenome ResearchPeer-reviewedJun 1, 2020

Identification of novel mutational signatures in Asian oral squamous cell carcinomas associated with bacterial infections

Arnoud Boot, Alvin Wei Tian Ng, Fui Teen Chong…·Steve Rozen

The paper identifies a novel mutational signature in Asian oral squamous cell carcinomas linked to bacterial infections, specifically colibactin.

58 citations

humanwhole-exome sequencing

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GenomicsbioRxivPreprintMay 22, 2020

Recurrent mutations in topoisomerase 2a cause a novel mutator phenotype in human cancers

Arnoud Boot, Steve Rozen

The paper identifies a novel mutator phenotype, ID_TOP2A, caused by the TOP2A p.K743N mutation, characterized by specific small indels and associated with tumorigenesis.

DOI 10.1101/2020.05.22.111666

human

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