Alvin Wei Tian Ng

This study identifies nucleophagy as the mechanism by which trapped PARP1 is cleared, showing that inhibiting this process re-sensitizes PARPi-resistant cells to PARPi.

The paper investigates the development and evolution of extrachromosomal DNA (ecDNA) in Barrett's esophagus patients progressing to esophageal adenocarcinoma, finding ecDNA is strongly associated with cancer progression and enriched for oncogenes and immunomodulatory genes.

The paper identifies a novel mutational signature in Asian oral squamous cell carcinomas linked to bacterial infections, specifically colibactin.

The paper identifies a unique mutational signature of glycidamide, a metabolite of acrylamide, through experimental and computational analysis, linking it to cancer genome patterns.