Author

Daniel S.W. Tan

National Cancer Centre SingaporeORCID 0000-0002-6514-6786Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 2 Genomics· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:statistical model· 2 Research Focus:variant calling· 2 Assay:whole-genome sequencing· 2 Research Focus:benchmarking· 1 Approach:deep learning· 1 Assay:DNA methylation· 1 Assay:whole-exome sequencing· 1

Frequent Co-Authors

Anders J. SkanderupiD· 2 shared Anna GaniD· 2 shared Denis OdinokoviD· 2 shared Hanaé CarriéiD· 2 shared Iain Bee Huat TaniD· 2 shared Lakshmi Narayanan LakshmananiD· 2 shared Polly S. Y. PooniD· 2 shared Yoon Sim YapiD· 2 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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2 shared papersBioinformatics

Anders J. SkanderupORCID

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Author profile →

3 papers

Recent·Most cited

Systematic benchmarking of multi-modal approaches for tumor-naive ctDNA detection and quantification

Ting Qi, Denis Odinokov, Lakshmi Narayanan Lakshmanan, Nathalia Graf Grachet, Melanie Lou, Seng Lor Saelee, Gladys Garcia-Montoya, Pui Mun Wong, Rafeed Chowdhury Rahman, Hosseinali Asgharian, Andrea Teh Xin Yi, Nicole Hnin Ye Pyone, Lan Ying Wang, Guat Tin Tan, Hanaé Carrié, , A. Skanderup

This study benchmarks tumor-naive ctDNA detection and quantification methods using WGS and methylation data from cancer patients, identifying performance trade-offs and optimal integration strategies.

bioRxiv · Jun 24, 2026 · PreprintBioinformatics

Fragle: Universal ctDNA quantification using deep learning of fragmentomic profiles

Guanhua Zhu, Chowdhury Rafeed Rahman, Victor Getty, Denis Odinokov, Probhonjon Baruah, Hanaé Carrié, Avril Joy Lim, Yu Amanda Guo, Zhong Wee Poh, Ngak Leng Sim, Ahmed Abdelmoneim, Yutong Cai, Lakshmi Narayanan Lakshmanan, Danliang Ho, Saranya Thangaraju, , Anders J. Skanderup

Fragle quantifies ctDNA from fragment length profiles using deep learning, showing high accuracy and improved detection limits across multiple datasets and sequencing types.

bioRxiv · Jul 28, 2023 · PreprintBioinformatics

Identification of novel mutational signatures in Asian oral squamous cell carcinomas associated with bacterial infections

Arnoud Boot, Alvin Wei Tian Ng, Fui Teen Chong, Szu-Chi Ho, Willie Yu, Daniel S.W. Tan, Narayanan Gopalakrishna Iyer, Steve Rozen

The paper identifies a novel mutational signature in Asian oral squamous cell carcinomas linked to bacterial infections, specifically colibactin.

Genome Research · Jun 1, 2020Peer-reviewedGenomics