Mosquito NF-κB-mediated innate immunity exerts arbovirus-specific antiviral effects at multiple stages of the viral life cycle
Philippa Hollinghurst, Lam Yin Cheung, Rayne Alexander, Tiffany Russell, Anthony C. Fredericks, Vikas Kumar, Louisa E. Wallace, Isabelle Dietrich, Tom A. Mendum, Andrew D. Davidson, Ana Fernández-Sesma, Kevin Maringer
This study shows that mosquito NF-κB-mediated immunity broadly suppresses arbovirus replication but has virus-specific effects, highlighting the complexity of antiviral barriers in mosquitoes.
bioRxiv · Nov 6, 2025 · PreprintMicrobiology