Mauricio Comas‐García

Mechanisms of viral budding through cellular membranes

The paper develops a theoretical model to explain how membrane geometry and boundary conditions influence viral budding completion, showing that vesicle-like geometries favor closure while flat membranes can stall.

Highly Conserved Core Residues Define Old-World Alphaviruses and Trace Early Evolutionary Divergence

The paper identifies conserved residues in Old-World alphaviruses that govern capsid structure and traces their evolutionary divergence, suggesting reduced assembly efficiency in New-World lineages may contribute to attenuation.

Multiple protein-protein interactions drive the assembly and budding of the Chikungunya virion

This study investigates Chikungunya virus assembly by combining simulations and experiments, showing that spike-spike interactions are critical for efficient budding and particle symmetry.