Shuyang Zhang

This study investigates Chikungunya virus assembly by combining simulations and experiments, showing that spike-spike interactions are critical for efficient budding and particle symmetry.

This paper identifies EPHX2 nuclear translocation as a mechanism to ameliorate cardiac dysfunction in Lmna-deficient mice using AAV-Cas9-based gene editing.

This study uses active learning to optimize medium components for selective culture of Lactobacillus plantarum and Escherichia coli, improving growth specificity through machine learning models trained on growth curve data.

The paper reports the structures of TSHR activated by TSH and an autoantibody, revealing a universal activation mechanism and the role of cholesterol in TSHR localization.

The paper reports cryo-EM structures of LHCGR in different activation states, revealing a push and pull mechanism of receptor activation and the role of an allosteric agonist.

The paper discovers suramin as a potent inhibitor of SARS-CoV-2 RNA polymerase and provides its structural mechanism for repurposing in treating COVID-19.

This study reports the structure of SARS-CoV-2 RdRp with and without Remdesivir, showing how the drug inhibits viral RNA replication by terminating chain elongation.

The paper investigates how different FBN1 truncating mutations cause distinct clinical phenotypes in Marfan syndrome and Marfanoid-progeroid-lipodystrophy syndrome through molecular and genetic analysis.