Author

Siyu Li

California State Polytechnic University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Biology Disciplines

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Biophysics· 2 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:protein structure· 1 Research Focus:protein structure prediction· 1 Approach:statistical model· 1

Frequent Co-Authors

Ajay GopinathaniD· 1 shared Ana Santa‐CruziD· 1 shared Andrew Zorn· 1 shared Carlos Villalba-Galea· 1 shared Chun-Chi CheniD· 1 shared Diomedes E. LogothetisiD· 1 shared Evangelo Dadiotis· 1 shared Georgios SkiniotisiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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1 shared paperBiophysics

Ajay GopinathanORCID

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3 papers

Recent·Most cited

Asymmetric assembly underlies activation mechanism of neuronal GIRK1/2 channels

Takeharu Kawano, Liang Wang, Kim W. Chan, Andrew Zorn, Nousheen Parvaiz, Mehreen Zaka, R. Charles Kissell, Carlos Villalba-Galea, Ana Santa‐Cruz, Yongcheng Lu, Nihal Aly, Jame Pentikis, Evangelo Dadiotis, Siyu Li, Meng Cui, , Diomedes E. Logothetis

This study reveals how asymmetric assembly of GIRK1/2 channels couples lipid-dependent gating to K+ permeation and pharmacological activation through structural and functional analyses.

bioRxiv · Oct 7, 2026 · PreprintBiophysics

Mechanisms of viral budding through cellular membranes

Shuyang Zhang, Siyu Li, Miguel Ángel Coronado-Ipiña, Mauricio Comas‐García, Ajay Gopinathan, Paul van der Schoot, Roya Zandi

The paper develops a theoretical model to explain how membrane geometry and boundary conditions influence viral budding completion, showing that vesicle-like geometries favor closure while flat membranes can stall.

The Journal of Chemical Physics · Sep 1, 2026Peer-reviewedBiophysics

Full-length structure of CPR-containing self-sufficient cytochrome P450

Zhenzhen Xie, Ziwei Liu, Siyu Li, Kangwei Xu, Jian‐Wen Huang, Jian Min, Q. T. Li, Jingxue Zhai, Te Wang, Yutong Wang, Lu Yang, Junjie Duan, Junjie Chen, Ruibo Wu, Chun-Chi Chen, Rey‐Ting Guo

The paper reports the structure of SoP450, a self-sufficient cytochrome P450, revealing its dimeric form and electron transfer mechanism.

bioRxiv · Nov 29, 2025 · PreprintSynthetic Biology