Author

David W. Kastner

Massachusetts Institute of TechnologyORCID 0000-0002-7766-4249Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1 Organism:plant (other)· 1 Approach:statistical model· 1

Frequent Co-Authors

Heather J. KulikiD· 2 shared Andrew J. Mitchell· 1 shared Antonio Del Rio FloresiD· 1 shared Catherine Luschinsky DrennaniD· 1 shared Colin Y. KimiD· 1 shared Edwin N. NeumanniD· 1 shared Jing‐Ke WengiD· 1 shared Jocelyn S. YaoiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersBiochemistry

Heather J. KulikORCID

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2 papers

Recent·Most cited

A second-sphere threonine residue directs iron-oxygen species in a Fe(II)/α-ketoglutarate-dependent isonitrile synthase

Naike Ye, Antonio Del Rio Flores, David W. Kastner, Kelsey R. Miller-Brown, Heather J. Kulik, Wenjun Zhang, Catherine Luschinsky Drennan

The paper identifies a second-sphere threonine residue that directs iron-oxygen species in an Fe(II)/α-ketoglutarate-dependent isonitrile synthase, revealing its role in catalytic regulation.

bioRxiv · Oct 30, 2026 · PreprintBiochemistry

Tracing the stepwise Darwinian evolution of a plant halogenase

Colin Y. Kim, David W. Kastner, Andrew J. Mitchell, Michael A. Gutierrez, Jocelyn S. Yao, Edwin N. Neumann, Heather J. Kulik, Jing‐Ke Weng

This study traces the evolutionary origin of a plant halogenase by showing it evolved from a flavonol synthase gene through duplication, neofunctionalization, and structural changes.

Science Advances · Aug 13, 2025Peer-reviewedBiochemistry