Edwin N. Neumann

A >50,000-element viral smORF library screened by growth, MHC-I, ER stress, Perturb-seq and mass spectrometry yields >2,000 active microproteins and shows EBV BNLF2b inhibits PKA by mimicry.

This study traces the evolutionary origin of a plant halogenase by showing it evolved from a flavonol synthase gene through duplication, neofunctionalization, and structural changes.

The paper shows that AF10, a DOT1L interaction partner, regulates H3K79 methylation levels and RNA polymerase II distribution to maintain cell identity and prevent reprogramming.