Author

Sabine Topka

Memorial Sloan Kettering Cancer CenterORCID 0000-0002-7767-4471Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1

Signature Assays, Organisms & Methods

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Assay:CRISPR screen· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1

Frequent Co-Authors

Daniel DurocheriD· 1 shared David B. SolitiD· 1 shared Elisa de StanchinaiD· 1 shared Gopa IyeriD· 1 shared Jian Carrot‐ZhangiD· 1 shared Joseph VijaiiD· 1 shared Kenneth OffitiD· 1 shared Kent William MouwiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperCancer Biology

Daniel DurocherORCID

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1 paper

Recent·Most cited

SLC25A28 is a synthetic lethal vulnerability in nucleotide excision repair-deficient cancers

Nan Yang, Lisa Hoeg, Xuechun Bai, Sizhi Gao, Elisa de Stanchina, David B. Solit, Sabine Topka, Sami Belhadj, Jian Carrot‐Zhang, Gopa Iyer, Daniel Durocher, Kent William Mouw, Joseph Vijai, Kenneth Offit, Steven M. Lipkin

This study identifies SLC25A28 as a synthetic lethal target in NER-deficient cancers, showing its loss impairs cell viability and increases oxidative stress.

bioRxiv · Oct 6, 2026 · PreprintCancer Biology