Jeremy D. Rotty

The Arp2/3 complex is required for in situ haptotactic response of microglia to iC3b

This study shows that the Arp2/3 complex is essential for microglia to respond haptotactically to iC3b, facilitating synaptic pruning through phagocytosis and migration.

Macrophages migrate persistently and directionally upon entering 2D confinement in the presence of extracellular matrix

This study shows that macrophages exhibit persistent directional migration when transitioning to a confined 2D environment, with enhanced persistence in the presence of a fibronectin gradient.

Physical confinement and phagocytic uptake induce directional migration

This study shows that physical confinement enhances phagocytosis in BV-2 microglia and induces directional migration, termed phagocytic priming, which depends on cytoskeletal factors and integrin adhesion.

Phactr4 influences macrophage lamellipodial structure and dynamics through Arp2/3 complex and Ezrin regulation

This study identifies Phactr4 as a regulator of macrophage lamellipodial dynamics through its interaction with Arp2/3 complex and regulation of ezrin phosphorylation.