Sophia Liu

Correlations of 276 missense variants of PSEN1, PSEN2, and APP on the production of Aβ peptides against variant effect predictors and biophysical structures

This study correlates 276 missense variants in PSEN1, PSEN2, and APP with Aβ peptide levels and variant effect predictors to assess pathogenicity in early-onset Alzheimer's disease.

Physical confinement and phagocytic uptake induce directional migration

This study shows that physical confinement enhances phagocytosis in BV-2 microglia and induces directional migration, termed phagocytic priming, which depends on cytoskeletal factors and integrin adhesion.

Intrastriatal delivery of a zinc finger protein targeting the mutant HTT gene by AAV9 obviates lipid phenotypes in brain and plasma of zQ175DN HD mice

The paper shows that reducing mutant HTT with a zinc finger protein in HD mice prevents lipid changes in brain and plasma.

Early whole-body mutant huntingtin lowering averts changes in proteins and lipids important for synapse function and white matter maintenance in the LacQ140 mouse model