Self-amplifying RNA-based CAR T cell therapy with enhanced duration and multi-genic logic functions
Yuyang Gu, Jaehoon Choi, Devin Mutha, Christopher Wu, Neil J. Ganem, Mark W. Grinstaff, Wilson W. Wong
This paper develops a self-amplifying RNA platform for CAR T cells that improves durability and enables multi-genic logic functions, showing superior tumor suppression in a leukemia model.
bioRxiv · Mar 21, 2026 · PreprintBioengineering