Author

León J. De Windt

Maastricht UniversityORCID 0000-0002-7793-2856Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:mouse· 3 Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:database / resource· 1 Organism:rat· 1 Approach:statistical model· 1

Frequent Co-Authors

Anika WitteniD· 2 shared Ellen Dirkx· 2 shared Federica De MajoiD· 2 shared Monika StolliD· 2 shared Paula A. da Costa MartinsiD· 2 shared Servé Olieslagers· 2 shared Shrey GandhiiD· 2 shared Andrea Raso· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersMolecular Biology

Anika WittenORCID

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Author profile →

3 papers

Recent·Most cited

LncRNA Bigheart trans-activates gene expression in a feed forward mechanism that facilitates calcineurin-NFAT signaling in myocardial hypertrophy

Nicolò Mangraviti, Frank Rühle, Virginie Kinet, Jana-Charlotte Hegenbarth, Ellen Dirkx, Giulia Spanò, Federica De Majo, Panagiotis Peppas, Leonie Martens, Shrey Gandhi, Robin M. W. Colpaert, Celia Rupérez, Servé Olieslagers, Inês Falcão‐Pires, Martina Calore, , León J. De Windt

This study identifies lncRNA Bigheart as a key regulator of calcineurin-NFAT signaling in myocardial hypertrophy, showing its role in driving maladaptive hypertrophy and susceptibility to heart failure.

bioRxiv · Dec 11, 2023 · PreprintMolecular Biology

Evolutionarily conserved transcriptional landscape of the heart defining the chamber specific physiology

Shrey Gandhi, Anika Witten, Federica De Majo, Martijn Daniël Gilbers, Jos G. Maessen, Ulrich Schotten, León J. De Windt, Monika Stoll

The paper identifies evolutionarily conserved transcriptional features in heart chambers across seven vertebrate species, revealing conserved genes, lncRNAs, and pathways relevant to cardiac physiology and disease.

Genomics · Sep 8, 2021Peer-reviewedGenomics

A microRNA program controls the transition of cardiomyocyte hyperplasia to hypertrophy and stimulates mammalian cardiac regeneration

Andrea Raso, Ellen Dirkx, Vasco Sampaio‐Pinto, Hamid el Azzouzi, Ryan John Cubero, Daniel W. Sorensen, Lara Ottaviani, Servé Olieslagers, Manon M. H. Huibers, Roel A. de Weger, Sailay Siddiqi, Silvia Moimas, Consuelo Torrini, Lorena Zentillin, Luca Braga, , León J. De Windt

This study identifies miR-106b~25 as a regulator of cardiomyocyte hyperplasia to hypertrophy transition and shows its ability to induce cardiac regeneration in adult mice.

Nature Communications · Aug 10, 2021Peer-reviewedMolecular Biology