Anika Witten

This study shows that heart muscle cell contractility suppresses proliferation and that inhibiting it allows cell cycle re-entry, suggesting contractility as a key regulator of cardiac regeneration.

The paper shows that male sex hormones and reduced plakoglobin impair atrial conduction and sodium currents in mice, contributing to atrial remodelling.

This study identifies lncRNA Bigheart as a key regulator of calcineurin-NFAT signaling in myocardial hypertrophy, showing its role in driving maladaptive hypertrophy and susceptibility to heart failure.

The paper identifies evolutionarily conserved transcriptional features in heart chambers across seven vertebrate species, revealing conserved genes, lncRNAs, and pathways relevant to cardiac physiology and disease.

The paper identifies a SNP in lncRNA H19 that alters its secondary structure and is associated with Dilated Cardiomyopathy, suggesting structural changes in lncRNAs may explain hidden genetic variance.