Frank Rühle

This study systematically profiles drug responses in BAF complex perturbations, revealing subtype-specific vulnerabilities and resistance patterns to genotoxic and cytotoxic compounds.

The paper shows SNRPN, a paralogue of SNRPB, stabilizes metabolic transcripts and enhances mitochondrial function, revealing a methylation-dependent mechanism for metabolic specialization in mammals.

This study maps sex-specific transcriptome dynamics in Anopheles gambiae embryos, revealing early sex-biased gene expression and dosage compensation mechanisms.

This study identifies convergent evolution of H4K16ac-mediated dosage compensation in a ZW species and links it to sex-dependent lifespan differences.

This study shows that inhibiting the DNMT/G9a complex targets specific epigenetic vulnerabilities in AML, inducing an IFN response and improving therapeutic outcomes.

The paper identifies over 5000 C-degrons in budding yeast and shows that the SCF ubiquitin ligase targets ~40% of them via the F-box receptor Das1.

This study identifies lncRNA Bigheart as a key regulator of calcineurin-NFAT signaling in myocardial hypertrophy, showing its role in driving maladaptive hypertrophy and susceptibility to heart failure.

The paper identifies a SNP in lncRNA H19 that alters its secondary structure and is associated with Dilated Cardiomyopathy, suggesting structural changes in lncRNAs may explain hidden genetic variance.