Yassine Sassi

This study shows that BMP3 overexpression reduces pulmonary vascular remodeling and cardiac dysfunction in PAH by balancing TGF-β and BMP pathways through paracrine signaling.

This study shows that blocking IL-6 restores FOXP3 expression in PAH, revealing its role as a biomarker and therapeutic target.

This study shows that inhibiting both ID1 and ID3 reduces pulmonary fibrosis in mice and human cells by blocking fibroblast proliferation and differentiation.

This study shows poor sleep worsens pulmonary arterial hypertension (PAH) by inducing inflammation and PASMC proliferation, forming a self-amplifying cycle that can be mitigated by improving sleep and reducing inflammation.

This paper develops orally deliverable milk-derived nanovesicles loaded with Cx43 peptides to treat cardiac ischemia-reperfusion injury, showing >60% reduction in infarct size in mice.