Author

Tomohiro Mizobata

Tottori UniversityORCID 0000-0002-7808-2099Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Organism:human· 1 Organism:mouse· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

Frequent Co-Authors

Ginji KomiyaiD· 2 shared Kazuya MatsuoiD· 2 shared Kenta KudoiD· 2 shared Norifumi ShiodaiD· 2 shared Susumu IkenoshitaiD· 2 shared Yasushi KawataiD· 2 shared Yasushi YabukiiD· 2 shared Atsushi TakedaiD· 1 shared

Activity by Year

2024-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersBiochemistry

Ginji KomiyaORCID

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2 papers

Recent·Most cited

RNA G-quadruplexes and calcium ions synergistically induce Tau phase transition in vitro

Yasushi Yabuki, Kazuya Matsuo, Ginji Komiya, Kenta Kudo, Karin Hori, Susumu Ikenoshita, Yasushi Kawata, Tomohiro Mizobata, Norifumi Shioda

This study shows RNA G-quadruplexes and calcium ions together promote Tau phase transition in vitro under physiological conditions.

Journal of Biological Chemistry · Nov 5, 2024Peer-reviewedBiochemistry

RNA G-quadruplexes forming scaffolds for alpha-synuclein aggregation lead to progressive neurodegeneration

Kazuya Matsuo, Sefan Asamitsu, Kohei Maeda, Hiroyoshi Suzuki, Kosuke Kawakubo, Ginji Komiya, Kenta Kudo, Yusuke Sakai, Karin Hori, Susumu Ikenoshita, Shingo Usuki, Shiori Funahashi, Hideki Oizumi, Atsushi Takeda, Yasushi Kawata, , Yasushi Yabuki

This study shows RNA G-quadruplexes scaffold alpha-synuclein aggregation, leading to neurodegeneration, and demonstrates that inhibiting this process can alleviate symptoms in a mouse model.

Cell · Oct 18, 2024Peer-reviewedMolecular Biology