Author

Chen He

Affiliated Hospital of North Sichuan Medical CollegeORCID 0000-0002-7810-5334Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 3 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 1 Assay:multiome· 1 Assay:proteomics· 1 Research Focus:spatial domain detection· 1 Approach:statistical model· 1

Frequent Co-Authors

Haitao SuniD· 2 shared Hao Tian· 2 shared Meichang Peng· 2 shared Meiqin Zeng· 2 shared Cheng XiaoiD· 1 shared Dongsheng ReniD· 1 shared Fangbo Xia· 1 shared Guang YangiD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersNeuroscience

Haitao SunORCID

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3 papers

Recent·Most cited

NeuroscienceInterdisciplinary medicinePeer-reviewedSep 22, 2026

Gut Microbiota Dysbiosis-Mediated Gut NLRP3 Inflammasome Activation Exacerbates Corticospinal Tract Injury After Intracerebral Hemorrhage

Meiqin Zeng, Meichang Peng, Chen He…·Haitao Sun

This study shows that gut microbiota dysbiosis activates the gut NLRP3 inflammasome, worsening CST injury after ICH through a gut-brain axis mechanism.

DOI 10.1002/inmd.70173

mouseexperimental assay

𝕏 PostBluesky

NeurosciencebioRxivPreprintNov 19, 2025

Gut metabolite IPA alleviates white matter injury post-ICH by enhancing myelin debris phagocytosis via Stap1 inhibition

Meichang Peng, Meiqin Zeng, Hao Tian…·Haitao Sun

This study shows that gut metabolite IPA reduces white matter injury after ICH by enhancing microglia phagocytosis of myelin debris through Stap1 inhibition.

1 citation

mouseproteomics

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Synthetic BiologybioRxivPreprintMar 29, 2023

Improving mRNA vaccine safety and efficiency with cationized lipid nanoparticle formula

Peng Xu, Guangneng Liao, Dongsheng Ren…·Kai Xu

This study modifies an mRNA-LNP vaccine formula with a cationic lipid to improve safety and efficiency, showing better immunogenicity and reduced off-target effects in mice.

4 citations

mousemultiome

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