Author

Bruna da Silva Soley

University of CincinnatiORCID 0000-0002-7810-6599Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:experimental assay· 1 Organism:human· 1 Approach:mechanistic / dynamical model· 1

Frequent Co-Authors

Jie WangiD· 1 shared Lindsey G. SiegfriediD· 1 shared Linli ZhouiD· 1 shared Mingang XuiD· 1 shared Sarah E. MillariD· 1 shared Thomas AndliD· 1 shared Yao XiaoiD· 1 shared Yuhang ZhangiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 28 mutual co-author links

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1 shared paperCancer Biology

Jie WangORCID

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1 paper

Recent·Most cited

Nuclear force transmission drives cancer-associated fibroblast activation under BRAF inhibition

Jie Wang, Bruna da Silva Soley, Yao Xiao, Lindsey G. Siegfried, Linli Zhou, Mingang Xu, Sarah E. Millar, Thomas Andl, Yuhang Zhang

This study identifies a mechanotransduction pathway in cancer-associated fibroblasts (CAFs) where BRAF inhibition and matrix stiffness converge to drive nuclear remodeling and CAF activation through the ROCK-cytoskeleton-nucleus axis.

bioRxiv · Jul 19, 2025 · PreprintCancer Biology