Cancer BiologybioRxivPreprint
Nuclear force transmission drives cancer-associated fibroblast activation under BRAF inhibition
Jie Wang, Bruna da Silva Soley, Yao Xiao…·Yuhang Zhang
This study identifies a mechanotransduction pathway in cancer-associated fibroblasts (CAFs) where BRAF inhibition and matrix stiffness converge to drive nuclear remodeling and CAF activation through the ROCK-cytoskeleton-nucleus axis.
1 citation