GeneticsbioRxivPreprint
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Parallel evolution under constraint shapes echinocandin resistance in Candida auris
Nicholas C. Cauldron, Erika N. Dort, Garrett Weeks…·Christina A. Cuomo
Across 681 matched isolates and 22,388 genomes, high-level micafungin resistance in Candida auris arises through recurrent FKS1 hotspot mutations amid strong purifying selection, and FKS2 appears dispensable.
DOI 10.64898/2026.08.30.748140