Phillip David Rogers

Parallel evolution under constraint shapes echinocandin resistance in Candida auris

Across 681 matched isolates and 22,388 genomes, high-level micafungin resistance in Candida auris arises through recurrent FKS1 hotspot mutations amid strong purifying selection, and FKS2 appears dispensable.

Acquired Amphotericin B Resistance Attributed to a Mutated ERG3 in Candidozyma auris

This paper describes a clinical case of acquired amphotericin B resistance in Candidozyma auris due to a frameshift mutation in ERG3, showing a fitness cost associated with altered sterol production.

Mutations in transcription factors that confer fluconazole resistance also confer reduced susceptibility to manogepix in Candida auris, Candida albicans, Candida parapsilosis, and Candida glabrata (Nakaseomyces glabratus)

The paper identifies mutations in transcription factors that confer fluconazole resistance and also reduce susceptibility to manogepix in multiple Candida species.

Mutations in TAC1B drive CDR1 and MDR1 expression and azole resistance in C. auris

This study shows that TAC1B mutations in C. auris increase fluconazole and triazole resistance by upregulating CDR1 and MDR1, with CDR1 being the main driver.

Analysis of clinical Candida parapsilosis isolates reveals copy number variation in key fluconazole resistance genes

The paper identifies copy number variations in fluconazole resistance genes in Candida parapsilosis isolates using whole-genome sequencing and GWAS.

Azole resistance is mediated by integration of sterol gene regulation and membrane transporter production by the zinc cluster-containing transcription factor Upc2A in Candida glabrata

This paper identifies Upc2A as a master regulator in Candida glabrata that coordinates sterol biosynthesis and membrane transporter production to mediate azole resistance.