Author

An Cheng

Sun Yat-sen UniversityORCID 0000-0002-7816-203XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:imaging· 1 Approach:statistical model· 1

Frequent Co-Authors

Adam L. BoxeriD· 1 shared Ahmed AbdelhakiD· 1 shared Aparna LakkarajuiD· 1 shared Ari GreeniD· 1 shared Azeen KeihaniiD· 1 shared Baiyao Liu· 1 shared Bruce L. MilleriD· 1 shared Christian CordanoiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperNeuroscience

Adam L. BoxerORCID

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2 papers

Recent·Most cited

NeuroscienceRedox BiologyPeer-reviewedApr 3, 2026

Astrocytic FABP5 drives non-cell-autonomous oligodendrocyte injury in multiple system atrophy by promoting TNF signaling and ferroptotic stress

Chuantao Wu, Jiejing Lin, Yi Chen…·An Cheng

This study identifies FABP5 as a key driver of astrocyte-mediated oligodendrocyte injury in MSA by promoting TNF signaling and ferroptotic stress.

DOI 10.1016/j.redox.2026.104150

𝕏 PostBluesky

NeurosciencebioRxivPreprintMay 29, 2024

Targeting complement C3a receptor resolves mitochondrial hyperfusion and subretinal microglial activation in progranulin-deficient frontotemporal dementia

Li Xuan Tan, Frederike Cosima Oertel, An Cheng…·Aparna Lakkaraju

This study identifies a mechanism by which progranulin deficiency leads to mitochondrial hyperfusion and neuroinflammation in GRN-FTD, showing that targeting C3aR can restore mitochondrial integrity and reduce microglial activation.

5 citations

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