Author

Azeen Keihani

University of California, BerkeleyORCID 0000-0002-9040-6535Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Assay:imaging· 1 Organism:mouse· 1

Frequent Co-Authors

Adam L. BoxeriD· 1 shared Ahmed AbdelhakiD· 1 shared An ChengiD· 1 shared Aparna LakkarajuiD· 1 shared Ari GreeniD· 1 shared Bruce L. MilleriD· 1 shared Christian CordanoiD· 1 shared Daniel J Bennett· 1 shared

Activity by Year

2024-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperNeuroscience

Adam L. BoxerORCID

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1 paper

Recent·Most cited

Targeting complement C3a receptor resolves mitochondrial hyperfusion and subretinal microglial activation in progranulin-deficient frontotemporal dementia

Li Xuan Tan, Frederike Cosima Oertel, An Cheng, Yann Cobigo, Azeen Keihani, Daniel J Bennett, Ahmed Abdelhak, Shivany Condor Montes, Makenna C. Chapman, Robert Yuzen Chen, Christian Cordano, Michael Emmerson Ward, Kaitlin Blackstone Casaletto, Joel H. Kramer, Howard J. Rosen, , Aparna Lakkaraju

This study identifies a mechanism by which progranulin deficiency leads to mitochondrial hyperfusion and neuroinflammation in GRN-FTD, showing that targeting C3aR can restore mitochondrial integrity and reduce microglial activation.

bioRxiv · May 29, 2024 · PreprintNeuroscience