Jonas M. Nikoloff

This paper shows that mutations in LRRK2 and GBA1 impair Hedgehog signaling in the striatum through distinct mechanisms, contributing to Parkinson's disease pathogenesis.

This study maps the cell state transitions during human blood vessel organoid development using single-cell transcriptomics and identifies key regulators and disease associations.

This paper develops human lung alveolar immuno-organoids with autologous immune cells to model immune-epithelial interactions and study inflammation-related pulmonary side effects.

This study shows LRRK2 and PINK1 function in parallel neuroprotective pathways affecting ciliogenesis in Parkinson's disease, suggesting shared therapeutic targets.

The paper shows that loss of primary cilia in specific striatal cell types reduces dopaminergic neuroprotection in Parkinson's disease, linked to impaired Hedgehog signaling.