Enrico Bagnoli

Endogenous LRRK2 and PINK1 function in a convergent neuroprotective ciliogenesis pathway in the brain

This study shows LRRK2 and PINK1 function in parallel neuroprotective pathways affecting ciliogenesis in Parkinson's disease, suggesting shared therapeutic targets.

Tagless LysoIP method for molecular profiling of lysosomal content in clinical samples

The paper develops a tagless LysoIP method to isolate lysosomes from clinical samples and human cell lines, revealing glycerophosphodiesters as potential biomarkers for lysosomal storage disorders.

Micromotion derived fluid shear stress mediates peri-electrode gliosis through mechanosensitive ion channels

This paper shows that fluid shear stress from micromotion around neural implants triggers gliosis via mechanosensitive ion channels, and modulating PIEZO1 affects astrocyte reactivity.