The structure, redox chemistry and motor neuron toxicity of heterodimeric zinc-deficient SOD1-Implications for the toxic gain of function observed in ALS.
Victor A. Streltsov, Katherine Ganio, Stewart D. Nuttall, J. Andres Hernandez, Cassandra N. Dennys, Peter John Crouch, Álvaro G. Estévez, María Clara Franco, Joseph S. Beckman, Blaine Russell Roberts
This study shows that zinc-deficient SOD1 forms toxic heterodimers with wild-type SOD1, contributing to ALS pathology through enhanced redox activity and motor neuron toxicity.
Neurobiology of Disease · Nov 16, 2025Peer-reviewedBiochemistry