Jonah Galeota-Sprung

Extracting anomalous diffusion parameters from multi-state ensembles of short single molecule trajectories.

The paper evaluates analysis methods for extracting diffusion parameters from single-molecule trajectories and shows that single-track analysis outperforms bulk methods.

Transcription condensates are promoter hubs that enhance transcriptional bursts

This study uses super-resolution microscopy to show that Pol II clusters form promoter hubs with layered chromatin organization, enhancing transcriptional bursts through cohesin loop extrusion.

Large RNA polymerase II condensates are promoter-centric assemblies associated with early stages of transcription at all expressed genes

The paper characterizes large RNA polymerase II condensates, showing they are promoter-centric and involved in early transcription stages across expressed genes.