Amoldeep S. Kainth

The paper shows WDR5 binds RNA non-specifically, displacing it from the MLL1 complex and inhibiting its catalytic activity.

The paper characterizes large RNA polymerase II condensates, showing they are promoter-centric and involved in early transcription stages across expressed genes.

The paper shows that Pol II CTD phosphorylation, specifically Ser2 phosphorylation, is critical for activating a heterochromatic gene in yeast, suggesting an alternative mechanism to histone modifications.

The paper develops a hybrid transcript assembly method combining short and long-read data to improve accuracy and sensitivity in full-length transcript reconstruction.

This study identifies inducible transcriptional condensates in yeast heat shock response and shows they drive 3D genome reorganization through Hsf1-mediated gene coalescence.

This study shows that Hsf1 drives intergenic interactions of HSP gene loci in yeast during heat shock, forming subnuclear foci that dissolve with transcriptional attenuation.