Alexander J. Ruthenburg

The paper shows WDR5 binds RNA non-specifically, displacing it from the MLL1 complex and inhibiting its catalytic activity.

The paper characterizes large RNA polymerase II condensates, showing they are promoter-centric and involved in early transcription stages across expressed genes.

This study identifies 79 cargos bound by IPO9, showing it recognizes proteins without cNLSs, and defines structural elements that mediate cargo selection and release.

This paper challenges the established model of actin import by showing IPO9 directly binds monomeric actin and competes with cofilin and profilin for actin binding.

This study identifies two RNA binding domains in YY1, including a newly discovered nucleic acid binding domain, and reveals autoinhibitory effects of the N-terminus on these domains.

The paper develops a hybrid transcript assembly method combining short and long-read data to improve accuracy and sensitivity in full-length transcript reconstruction.

The paper identifies the Mediator Kinase Module's role in DNA damage response and transcriptional regulation across species.

The paper reevaluates H3K4 methylation analysis using specific antibodies and highlights issues with previous studies using less specific reagents.

The paper introduces CoLa-seq to profile splicing timing and identifies genetic factors influencing co-transcriptional splicing in human cells.

This study re-evaluates the bivalency model using a new ChIP method, finding widespread bivalency that does not resolve with differentiation and is not specific for poised developmental genes.

The paper introduces a new computational pipeline, Tuxedo, for analyzing nuclear RNA-seq data, which identifies chromatin-enriched RNAs (cheRNAs) and characterizes their cis-regulatory roles.

This study identifies WDR76 as a hmC-specific protein that promotes MLL-rearranged leukemia by modulating gene expression and facilitating leukemogenesis.