Improved protein glycosylation enabled heterologous biosynthesis of monoterpenoid indole alkaloids and their unnatural derivatives in yeast
Mohammadamin Shahsavarani, Joseph Christian Utomo, Rahul Kumar, Melina Paz‐Galeano, Jorge Jonathan Oswaldo Garza‐García, Zhan Mai, Dae‐Kyun Ro, Yang Qu
This study improves yeast-based biosynthesis of monoterpenoid indole alkaloids by expressing a key enzyme and integrating biosynthetic gene cassettes, enabling production of vinblastine precursors and their unnatural derivatives.
Metabolic Engineering Communications · Dec 5, 2022Peer-reviewedSynthetic Biology