Martín E. Fernández-Zapico

Longitudinal Analysis of Matched Patient Biospecimens Reveals Neural Reprogramming of Cancer-Associated Fibroblasts Following Chemotherapy in Pancreatic Cancer

The paper analyzes matched pre- and post-chemotherapy biospecimens in pancreatic cancer, revealing that cancer-associated fibroblasts undergo neural reprogramming, characterized by axonal guidance gene enrichment, which may contribute to chemoresistance and tumor progression.

Pancreatic tumor microenvironment reprogramming via alloantigen-expressing virotherapy elicits tumor rejection and improves immunotherapy response

Oncolytic virus-based delivery of an alloantigen improves antitumor immunity and synergizes with immune checkpoint inhibitors in pancreatic cancer.

Spatial Conformation of Pancreatic Cancer Is Associated with Disease Recurrence after Curative-Intent Total Neoadjuvant Therapy

This paper quantifies spatial cancer-stroma topology in post-TNT PDAC and shows it independently predicts disease-free survival better than traditional response assessments.

Tumor Landscape Analysis: An Ecologically Informed Framework to Understand Tumor Microenvironments

The paper introduces TLA, a computational framework using ecological principles to analyze tumor spatial heterogeneity and link it to clinical outcomes.