Specific Deletion of Axin1 Leads to Activation of β-Catenin/BMP Signaling Resulting in Fibular Hemimelia Phenotype in Mice
Rong Xie, Dan Yi, Daofu Zeng, Qiang Jie, Qinglin Kang, Zeng Zhang, Zhenlin Zhang, Guozhi Xiao, Lin Chen, Liping Tong, Di Chen
This study shows that Axin1 deletion in mice causes fibular hemimelia by disrupting β-catenin and BMP signaling during limb development.
eLife · Dec 21, 2022Peer-reviewedDevelopmental Biology