Sandeep M. Eswarappa

The paper identifies a conserved four-codon dORF in the 3'UTR of MAP3K10 regulated by an RNA G-quadruplex, which modulates MAP3K10 expression.

The paper describes a nine-amino-acid degron derived from MTCH2's 3'UTR that enables tunable protein degradation via the ubiquitin-proteasome system.

The paper introduces an in vivo assay to study gene expression regulation without animal sacrifice, demonstrating its use for promoter, microRNA, stop codon readthrough, and rare codon effects.

This paper describes a CRISPR-dCas13 system to induce stop codon readthrough in specific transcripts, showing enhanced readthrough in AGO1, VEGFA, and HBB mRNAs.