Author

Lekha E. Manjunath

Indian Institute of Science Bangalore

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Assay:CRISPR screen· 1 Organism:mouse· 1 Research Focus:perturbation response prediction· 1 Research Focus:protein design· 1 Assay:proteomics· 1 Organism:yeast· 1

Frequent Co-Authors

Sandeep M. EswarappaiD· 3 shared Anumeha SinghiD· 2 shared Kirtana Vasu· 2 shared Saubhik SomiD· 2 shared Anubhav DhariD· 1 shared Debaleena Kar· 1 shared Debraj MannaiD· 1 shared Eepsitha Eepsitha· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersMolecular Biology

Sandeep M. EswarappaORCID

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3 papers

Recent·Most cited

A compact, portable degron tool derived from the 3'UTR of MTCH2 for tunable degradation of proteins

Lekha E. Manjunath, Saubhik Som, Ramon Boro, Anubhav Dhar, Eepsitha Eepsitha, Saravanan Palani, Sandeep M. Eswarappa

The paper describes a nine-amino-acid degron derived from MTCH2's 3'UTR that enables tunable protein degradation via the ubiquitin-proteasome system.

bioRxiv · Feb 5, 2026 · PreprintMolecular Biology

IVISc-L: A quick and simple in vivo assay to study the regulation of gene expression

Saubhik Som, Gopalapura J. Vishalakshi, Lekha E. Manjunath, Debraj Manna, Kirtana Vasu, Anumeha Singh, Sandeep M. Eswarappa

The paper introduces an in vivo assay to study gene expression regulation without animal sacrifice, demonstrating its use for promoter, microRNA, stop codon readthrough, and rare codon effects.

bioRxiv · Dec 16, 2024 · PreprintMolecular Biology

Transcript-specific induction of stop codon readthrough using CRISPR-dCas13 system

Lekha E. Manjunath, Anumeha Singh, Sangeetha Devi Kumar, Kirtana Vasu, Debaleena Kar, Sellamuthu Karthi, Sandeep M. Eswarappa

This paper describes a CRISPR-dCas13 system to induce stop codon readthrough in specific transcripts, showing enhanced readthrough in AGO1, VEGFA, and HBB mRNAs.

EMBO Reports · Mar 18, 2024Peer-reviewedMolecular Biology