Roberto Vázquez

PhaLP 2.0: extending the community-oriented phage lysin database with a SUBLYME pipeline for metagenomic discovery

PhaLP 2.0 enhances a phage lysin database by integrating metagenomic data and introducing SUBLYME, a machine learning tool that identifies and classifies lysins with high accuracy.

SPAED: Harnessing AlphaFold Output for Accurate Segmentation of Phage Endolysin Domains

SPAED improves domain segmentation in phage endolysins using AlphaFold's PAE matrix, achieving higher accuracy than Chainsaw.

Diversity, structure-function relationships and evolution of cell wall-binding domains of staphylococcal phage endolysins

This study analyzes the structure-function relationships and evolutionary origins of cell wall-binding domains in staphylococcal phage endolysins, finding that CBD specificity is not strongly correlated with phylogeny or host specificity.

The new SH3_T domain increases the structural and functional variability among SH3b-like CBDs from staphylococcal phage endolysins

This paper identifies a new SH3b_T family of CBDs in staphylococcal phage endolysins and shows how sequence differences and EAD-CBD combinations influence binding specificity and activity.

Monomodular Pseudomonas aeruginosa phage JG004 lysozyme (Pae87) contains a bacterial surface-active antimicrobial peptide-like region and a possible substrate-binding subdomain

This paper characterizes the antimicrobial activity of Pae87, a phage lysin from Pseudomonas aeruginosa, revealing a C-terminal antimicrobial peptide-like region critical for cell wall disruption.