Yves Briers

PhaLP 2.0 enhances a phage lysin database by integrating metagenomic data and introducing SUBLYME, a machine learning tool that identifies and classifies lysins with high accuracy.

The paper develops a funnel-type pipeline for designing and testing designer xylanosomes to efficiently break down arabinoxylan, identifying optimal variants for biomass valorization.

The paper introduces KlebPhaCol, a resource containing 53 phages and 74 Klebsiella isolates, including a novel gut phage order, to advance understanding of Klebsiella-phage interactions.

SPAED improves domain segmentation in phage endolysins using AlphaFold's PAE matrix, achieving higher accuracy than Chainsaw.

The paper catalogs 105 recombinant Klebsiella phage depolymerases, classifying them by sequence, structure, and substrate specificity, revealing diverse enzyme functions and evolutionary patterns.

This study analyzes the structure-function relationships and evolutionary origins of cell wall-binding domains in staphylococcal phage endolysins, finding that CBD specificity is not strongly correlated with phylogeny or host specificity.

This paper introduces a VersaTile platform to engineer R2 tailocins with broad specificity against multiple E. coli and Klebsiella pneumoniae serotypes, achieving high efficacy and cross-species activity.

DepoScope uses large language models to accurately annotate phage depolymerases and their domains, improving detection through sequence and amino-acid level predictions.

This paper identifies a new SH3b_T family of CBDs in staphylococcal phage endolysins and shows how sequence differences and EAD-CBD combinations influence binding specificity and activity.

This paper introduces a bioluminescence-based ex vivo burn wound model to assess antibacterial compounds in real-time, validated with an engineered lysin.

This study analyzes Pseudomonas aeruginosa virus PA5oct using hybrid sequencing and proteomics to reveal its genomic structure, transcription dynamics, and interactions with host bacteria.

This paper introduces Innolysins, engineered endolysins fused with phage receptor binding proteins to overcome the outer membrane of Gram-negative bacteria, demonstrating bactericidal activity against E. coli and related species.