Jeanne E. Hendrickson

This study builds prediction models for RBC alloimmunization using statistical and machine learning methods on the REDS-III database, finding XGBoost provides the best performance with an AUC-ROC of 0.752.

This study shows that RBC transfusion induces weak IgG class switching compared to vaccination, due to suboptimal T cell help, and activates T cells via a non-canonical pathway.

This study shows splenic MARCO+ marginal zone macrophages (MZMs) enhance cytokine production but are not required for anti-RBC alloantibody generation after stored RBC transfusion in mice.