James C. Zimring

Genetic architecture of the murine serum metabolome reveals carboxyl esterases as master regulators of circulating fatty acid metabolism

The paper identifies genetic regulators of the murine serum metabolome, highlighting carboxyl esterases as key controllers of fatty acid metabolism.

Deep Red Blood Cell Proteome Defines the Band 3 N-Terminus Interactome as a Regulator of Hypoxic Adaptation via BLVRB-Dependent S-Nitroso Transfer

The paper defines the Band 3 N-terminus interactome in red blood cells, revealing its role in hypoxic adaptation through BLVRB-dependent S-nitroso transfer and metabolic remodeling.

Structural divergence of G6PD variants shapes red blood cell storage and transfusion performance

The paper investigates how G6PD variants affect red blood cell storage, transfusion performance, and recipient physiology using multiple datasets and experimental models.

Caffeine Impairs Red Blood Cell Storage Quality by Dual Inhibition of ADORA2b Signaling and G6PD Activity

Caffeine consumption and ADORA2b genetic variants impair RBC metabolism and transfusion outcomes through dual mechanisms, highlighting a modifiable interaction for precision transfusion strategies.

Red Blood Cell Transfusion is a Non-Canonical Immune Stimulus Characterized by the Suboptimal Induction of CD4+ T Cell Help

This study shows that RBC transfusion induces weak IgG class switching compared to vaccination, due to suboptimal T cell help, and activates T cells via a non-canonical pathway.

Genetic architecture of the red blood cell proteome in genetically diverse mice reveals central role of hemoglobin beta cysteine redox status in maintaining circulating glutathione pools

The paper identifies genetic factors influencing red blood cell proteome and oxidative stress in mice, highlighting hemoglobin cysteine redox status as critical for glutathione regulation.

Splenic MARCO+ marginal zone macrophages regulate rapid production of MCP-1 and KC but are dispensable for alloantibody generation in response to stored RBCs in a murine model.

This study shows splenic MARCO+ marginal zone macrophages (MZMs) enhance cytokine production but are not required for anti-RBC alloantibody generation after stored RBC transfusion in mice.

Transfusion of allogenic murine HOD red blood cells preferentially induces low-affinity, short-lived IgG antibodies that are germinal center independent

Ferroptosis regulates hemolysis in stored murine and human red blood cells

This study identifies Steap3 as a regulator of ferroptosis-like lipid peroxidation in stored RBCs, linking genetic variants to hemolysis in mice and human blood donors.