Overexpression of human alpha-synuclein leads to dysregulated microbiome and metabolites with ageing in a rat model of Parkinson disease
Yogesh Singh, Christoph Trautwein, Joan Romani, Madhuri S. Salker, Peter H. Neckel, Isabel Fraccaroli, Mahkameh Abeditashi, Nils Woerner, Jakob Admard, Achal Dhariwal, Morten Simonsen Dueholm, Karl‐Herbert Schäfer, Florian J.W. Lang, Daniel E. Otzen, Hilal Ahmed Lashuel, , Nicolas Casadei
This study shows that overexpression of human alpha-synuclein in rats leads to gut microbiome dysbiosis, altered metabolites, and aging-related changes that can be modulated by antibiotics.
Molecular Neurodegeneration · Jul 4, 2023Peer-reviewedNeuroscience