Lipid bilayers determine the allostery but not intrinsic affinity of cAMP binding to pacemaker channels
Vinay Kumar Idikuda, Susovan Roy Chowdhury, Audrey Chinn, Yongchang Chang, Suhaila Rahman, Qian Ren, Huan Bao, Ziao Fu, Randall H. Goldsmith, Baron Chanda
This study shows lipid bilayers enable cooperative cAMP binding to HCN channels but do not affect intrinsic binding affinity, revealing a role for membranes in enhancing inter-subunit interactions.
Nature Communications · May 2, 2026Peer-reviewedBiophysics