Huan Bao

This paper introduces IR-AMES, a technique for ultrasensitive structural and compositional analysis of individual biomolecular assemblies in aqueous environments, revealing insights into tau oligomers and their interactions with membranes.

This paper develops nanodiscs for targeted delivery of an anti-inflammatory drug to macrophages in AAA, showing reduced disease progression in mice.

This study investigates how Munc18 interacts with Syntaxin and SNAP25 in model membranes, showing lipid-dependent effects on SNARE complex assembly and exocytosis.

This study shows lipid bilayers enable cooperative cAMP binding to HCN channels but do not affect intrinsic binding affinity, revealing a role for membranes in enhancing inter-subunit interactions.

This paper introduces DeFrNDs, detergent-free nanodiscs made with engineered membrane scaffold peptides, enabling high-resolution structural analysis of membrane proteins in native lipid environments.

The paper introduces variants of the glutamate sensor iGluSnFR with improved brightness, broader concentration detection, and different emission colors for enhanced in vivo imaging.