Zhi‐Hong Jiang

This study identifies mannosyl-queuosine (manQ) as an age-related tRNA modification that declines across species and is reversed by queuine supplementation, improving healthspan and lifespan.

This study determines the structure of KCNQ1+KCNE1 in closed and open states, revealing structural transitions and dual PIP2 binding that regulate channel gating and IKs function.

This study identifies Npac as a co-factor of H3K36me3 that regulates transcriptional elongation in mouse ESCs by interacting with p-TEFb and RNA Pol II.