Author

Tong‐Meng Yan

Macau University of Science and TechnologyORCID 0009-0002-5770-1791Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Approach:biophysical modeling· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Organism:Drosophila· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Kai‐Yue CaoiD· 2 shared Rui‐Ze GongiD· 2 shared Yating ChengiD· 2 shared Da Zhang· 1 shared Liu‐Ying MoiD· 1 shared Long‐Bo Bai· 1 shared Yu PaniD· 1 shared Yu PaniD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersPharmacology & Toxicology

Kai‐Yue CaoORCID

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2 papers

Recent·Most cited

Pharmacology & ToxicologybioRxivPreprintMar 24, 2026

Evolutionarily Conserved Decline of tRNA Mannosyl-Queuosine Links Translational Regulation to Aging and Is Reversed by Queuine

Rui‐Ze Gong, Tong‐Meng Yan, Yu Pan…·Zhi‐Hong Jiang

This study identifies mannosyl-queuosine (manQ) as an age-related tRNA modification that declines across species and is reversed by queuine supplementation, improving healthspan and lifespan.

2 citations

humanmouse

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GeneticsbioRxivPreprintMar 24, 2025

Targeted intervention of senescence induced by a 5' half fragment of tRNASec(NCA) with antisense oligonucleotide extends healthspan and lifespan in mice

Kai‐Yue Cao, Long‐Bo Bai, Da Zhang…·Zhi-Hong Jiang

This study identifies tRNASec(NCA) damage as an aging hallmark and shows that targeting its 5'-fragment with ASO extends healthspan and lifespan in mice.

DOI 10.1101/2025.03.24.644848

mouseexperimental assay

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