Starvation sensing by mycobacterial RelA/SpoT homologue through constitutive surveillance of translation
Yunlong Li, Soneya Majumdar, Ryan Z. Treen, Manjuli Rani Sharma, Jamie H. Corro, Howard Gamper, Swati R. Manjari, Jerome Prusa, Nilesh K. Banavali, Christina L. Stallings, Ya‐Ming Hou, Rajendra Kumar Agrawal, Anil Kumar Ojha
This study identifies how mycobacterial Rsh detects deacylated tRNA in translating ribosomes through structural and functional analysis, revealing its constitutive surveillance mechanism.
Proceedings of the National Academy of Sciences · May 22, 2023Peer-reviewedMolecular Biology